A selective inhibitor of PDE3A and PDE3B (IC50s = 27 and 50 nM

Cilostamide – 10 mg

Brand:
Cayman
CAS:
68550-75-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.{19198} It is less selective for inhibition of PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 12 to > 300 μM).{19198} Cilostamide has been shown to inhibit thrombin-induced platelet aggregation with an IC50 value of 1.1 μM.{19198}  

 

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Description

A selective inhibitor of PDE3A and PDE3B (IC50s = 27 and 50 nM, respectively); inhibits thrombin-induced platelet aggregation (IC50 = 1.1 μM)

Formal name: N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-butanamide

Synonyms:  OPC 3689

Molecular weight: 342.4

CAS: 68550-75-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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