An inhibitor of CaM

Calmidazolium (chloride) – 10 mg

Brand:
Cayman
CAS:
57265-65-3
Storage:
-20
UN-No:
Non-Hazardous - /

Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively).{23338} Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 µM, respectively).{23338} It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 µM).{23337,23336}  

 

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Description

An inhibitor of CaM, inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively); also inhibits an array of calcium-transporting ATPases (IC50 = 2.1 and 2.9 µM, respectively)

Formal name: 3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazolium, monochloride

Synonyms:  R 24571

Molecular weight: 687.7

CAS: 57265-65-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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