A bpV compound that selectivity inhibits PTEN (IC50 = 31 nM); also inhibits the vascular endothelial PTP

bpV(pic) (potassium hydrate) – 5 mg

Brand:
Cayman
CAS:
148556-27-8
Storage:
-20
UN-No:
Non-Hazardous - /

bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM).{22177} It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM).{22177} bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes.{22162}  

 

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Description

A bpV compound that selectivity inhibits PTEN (IC50 = 31 nM); also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM) and is known to be an insulin mimetic capable of activating the insulin receptor kinase

Formal name: (PB-7-23-111’1’4)-oxodiperoxy(2-pyridinecarboxylato-κN1,κO2)-vanadate(2-), dipotassium, dihydrate

Synonyms:  Bisperoxovanadium(pic)

Molecular weight: 367.3

CAS: 148556-27-8

Purity: ≥96%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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