A cell-permeable analog of cAMP that activates PKA with a Ka value of 0.05 μM; more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP

8-bromo-Cyclic AMP (sodium salt) – 10 mg

Brand:
Cayman
CAS:
76939-46-3
Storage:
-20
UN-No:
Non-Hazardous - /

8-bromo-Cyclic AMP (8-bromo-cAMP) is a cell-permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM.{22886} It activates cyclic-GMP-dependent protein kinase with 100-fold reduced potency (Ka = 5.8 μM).{22886} 8-bromo-cAMP is more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP.{22886}  

 

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Description

A cell-permeable analog of cAMP that activates PKA with a Ka value of 0.05 μM; more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP

Formal name: 8-bromo-cyclic 3′,5′-(hydrogen phosphate)-adenosine, monosodium salt

Synonyms:  8-bromo-cAMP|8-Bromoadenosine 3′,5′-cyclic monophosphate

Molecular weight: 430.1

CAS: 76939-46-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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