An ATP-competitive

Alsterpaullone – 1 mg

Brand:
Cayman
CAS:
237430-03-4
Storage:
-20
UN-No:
Non-Hazardous - /

Alsterpaullone is a derivative of kenpaullone (Item No. 10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.{22493,14995} Alsterpaullone has been used to inhibit the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer’s disease, and to alter cell proliferation or protein expression in various diseases.{22492,22495,22494}  

 

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Description

An ATP-competitive, selective inhibitor of Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25 and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.

Formal name: 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

Synonyms:  9-Nitropaullone|NSC 705701

Molecular weight: 293.3

CAS: 237430-03-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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