Description
A natural kavalactone that enhances the binding of bicuculline at the GABA receptor GABAA at 1.0 µM; binds the CB1 receptor with a Ki value of 0.72 µM; blocks the activation of NF-κB by TNF-α; inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL)
Formal name: 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one
Synonyms:
Molecular weight: 258.3
CAS: 500-62-9
Purity: ≥98%
Formulation: A crystalline solid
Application||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors
