8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943

8-iso Prostaglandin E2 – 500 µg

Brand:
Cayman
CAS:
27415-25-4
Storage:
-20
UN-No:
Non-Hazardous - /

8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 µg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}  

 

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8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.{1943} It is a potent renal vasoconstrictor in the rat.{1943,5157} 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.{1258} When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.{1943}

Formal name: 9-oxo-11α,15S-dihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid

Synonyms:  8-epi PGE2|8-iso PGE2

Molecular weight: 352.5

CAS: 27415-25-4

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Isoprostanes||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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