A serotonin and norepinephrine reuptake inhibitor (Kis = 4.6 and 15.6 nM

(S)-Duloxetine (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
136434-34-9
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes).{25641} It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively).{25642} It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg.{41773} Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.  

 

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Description

A serotonin and norepinephrine reuptake inhibitor (Kis = 4.6 and 15.6 nM, respectively); also inhibits dopamine reuptake (Ki = 369 nM); suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively); has antidepressant-like activity in mice in the forced swim test at 16 and 32 mg/kg

Formal name: N-methyl-γS-(1-naphthalenyloxy)-2-thiophenepropanamine, monohydrochloride

Synonyms:  LY248686

Molecular weight: 333.9

CAS: 136434-34-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Pain Research

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