A fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml); when used as a broad-spectrum oral antibiotic

Gatifloxacin – 1 g

Brand:
Cayman
CAS:
112811-59-3
Storage:
-20
UN-No:
Non-Hazardous - /

Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml).{22453} It is much less effective against HeLa cell topoisomerase II (IC50 = 265 μg/ml).{22453} Gatifloxin has been used as a broad-spectrum oral antibiotic, but it can produce dysglycemia in older adults.{22452} It remains useful for resolving bacterial conjunctivitis.{22451}  

 

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Description

A fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml); when used as a broad-spectrum oral antibiotic, can produce dysglycemia in older adults; useful for resolving bacterial conjunctivitis

Formal name: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Synonyms:  AM1155|BMS 206584-01|PD 135432

Molecular weight: 375.4

CAS: 112811-59-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Aminoglycosides||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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