A sesquiterpene lactone which protects against cerebral edema

Bilobalide – 10 mg

Brand:
Cayman
CAS:
33570-04-6
Storage:
-20
UN-No:
Non-Hazardous - /

Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage.{22388} Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions.{22385,22386} It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.{22387,22384}  

 

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Description

A sesquiterpene lactone which protects against cerebral edema, decreases cortical infarct volume, and reduces cerebral ischemic damage; at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions; increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes

Formal name: (3aS,5aR,8aS)-9R-(1,1-dimethylethyl)-10,10aS-dihydro-8R,9-dihydroxy-4H,5aH,9H-furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione

Synonyms: 

Molecular weight: 326.3

CAS: 33570-04-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Activators||Research Area|Neuroscience|Neuroprotection|Ischemia

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