A plant alkaloid that demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex

Luotonin F – 1 mg

Brand:
Cayman
CAS:
244616-85-1
Storage:
-20
UN-No:
Non-Hazardous - /

Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.{22184} It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.{22184,25352,25350}  

 

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Description

A plant alkaloid that demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex

Formal name: 2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone

Synonyms: 

Molecular weight: 301.3

CAS: 244616-85-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation

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