An alkaloid that inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml); binds to and stabilizes the topoisomerase I-DNA binary complex

Luotonin A – 5 mg

Brand:
Cayman
CAS:
205989-12-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.{22184} It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).{22184} Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).{25352} Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.{25350} Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.{25351}  

 

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Description

An alkaloid that inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml); binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM); selectively inhibits CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes

Formal name: quino[2′,3′:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one

Synonyms: 

Molecular weight: 285.3

CAS: 205989-12-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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