A GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes); decreases the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons; increases the number of entries into the open arms of the elevated plus maze in BALB/c

Flumazenil – 10 mg

Brand:
Cayman
CAS:
78755-81-4
Storage:
-20
UN-No:
Non-Hazardous - /

Flumazenil is a GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes).{53225} Flumazenil also acts as a partial agonist of GABAA receptors, decreasing the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons.{53226} It increases the number of entries into the open arms of the elevated plus maze in high-anxiety BALB/c, but not C57BL/6, mice when administered at doses ranging from 0.1 to 1,000 µg/kg.{53227} Flumazenil (5 and 10 mg/kg) prevents a reduction in burying behavior induced by the GABAA receptor positive allosteric modulator allopregnanolone (Item No. 16930) in ovariectomized rats when administered at doses of 5 and 10 mg/kg.{53228} Formulations containing flumazenil have been used to reverse sedation induced by benzodiazepines and in the treatment of benzodiazepine overdose or withdrawal.  

 

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Description

A GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes); decreases the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons; increases the number of entries into the open arms of the elevated plus maze in BALB/c, but not C57BL/6, mice from 0.1-1,000 µg/kg; prevents allopregnanolone-induced reduction of burying behavior in ovariectomized rats at 5 and 10 mg/kg,,

Formal name: 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Synonyms:  Ro 15-1788|Ro 1722|Ro 41-8157

Molecular weight: 303.3

CAS: 78755-81-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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