A DR5 agonist (Kd= 1.2 µM; IC50 = 2 µM) that induces DR5 clustering

Bioymifi – 5 mg

Brand:
Cayman
CAS:
1420071-30-2
Storage:
-20
UN-No:
Non-Hazardous - /

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), a member of this family, activates apoptosis in a variety of tumor cell lines by signaling through the death receptors, DR4 and DR5. Bioymifi directly activates DR5 (Kd = 1.2 µM; IC50 = 2 µM), inducing DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.{29884}  

 

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Description

A DR5 agonist (Kd= 1.2 µM; IC50 = 2 µM) that induces DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells

Formal name: 5-[5-[[3-(4-bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione

Synonyms: 

Molecular weight: 494.3

CAS: 1420071-30-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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