An amphetamine that increases extracellular NE and DA with potencies similar to D-amphetamine (EC50s of 22.2 and 7.2 nM for NE and 44.1 and 8.0 nM for DA

4-Methylamphetamine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
41632-56-8
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylamphetamine (4-MA) (hydrochloride) (Item No. 14215) is an analytical reference standard categorized as an amphetamine. 4-MA acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase extracellular levels of these neurotransmitters. In vitro, the potencies of 4-MA for NE and DA release are similar to those of D-amphetamine with EC50 values of 22.2 and 7.2 nM for NE and 44.1 and 8.0 nM for DA, respectively.{36006} 4-MA is more potent than D-amphetamine at releasing serotonin (EC50s = 53.4 and 1,756 nM, respectively). In rats, 4-MA acts as an agonist at 5-HT1A receptors and induces hypothermia.{36005} It is found as a contaminant in amphetamine, and ingestion has been associated with severe intoxication and fatalities.{36004} This product is intended for research and forensic applications.  

 

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Description

An amphetamine that increases extracellular NE and DA with potencies similar to D-amphetamine (EC50s of 22.2 and 7.2 nM for NE and 44.1 and 8.0 nM for DA, respectively); more potent than D-amphetamine in release of 5-HT (EC50s = 53.4 and 1,756 nM, for 4-MA and D-amphetamine, respectively); found as a contaminant in amphetamine; associated with severe intoxication and fatalities,

Formal name: α,4-dimethyl-benzeneethanamine, monohydrochloride

Synonyms:  p-Methylamphetamine|para-Methylamphetamine|4-MA

Molecular weight: 185.7

CAS: 41632-56-8

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Forensic Chemistry & Toxicology|Performance-Enhancing Drugs|Stimulants||Research Area|Forensic Chemistry & Toxicology|Stimulants|Amphetamines

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