5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.{2213} It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates.{2180} 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator.{2177} It also inhibits platelet aggregation in human PRP with an IC50 of 180 nM.{1607}

5-trans Prostaglandin E2 – 5 mg

Brand:
Cayman
CAS:
36150-00-2
Storage:
-20
UN-No:
Non-Hazardous - /

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.{2213} It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates.{2180} 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator.{2177} It also inhibits platelet aggregation in human PRP with an IC50 of 180 nM.{1607}  

 

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Description

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.{2213} It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates.{2180} 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator.{2177} It also inhibits platelet aggregation in human PRP with an IC50 of 180 nM.{1607}

Formal name: 9-oxo-11α,15S-dihydroxy-prosta-5E,13E-dien-1-oic acid

Synonyms:  trans-Dinoprostone|5,6-trans PGE2

Molecular weight: 352.5

CAS: 36150-00-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Pharmaceutical Impurities||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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