Inhibits Gli1-mediated transcription (EC50 = 5 μM) in a variety of cell types disrupting the hh signaling pathway downstream of Smo and Sufu; displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells

GANT 58 – 50 mg

Brand:
Cayman
CAS:
64048-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 58 is a GLI antagonist that inhibits GLI1-mediated transcription (EC50 = 5 μM) in a variety of cell types.{22122,22692,22693} It inhibits the hh signaling pathway downstream of Smo and the endogenous downstream inhibitor Sufu thereby affecting GLI1 nuclear accumulation.{22122} GANT 58 displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.{22692,22693}  

 

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Description

Inhibits Gli1-mediated transcription (EC50 = 5 μM) in a variety of cell types disrupting the hh signaling pathway downstream of Smo and Sufu; displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells

Formal name: 4,4’,4’’,4’’’-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine

Synonyms:  NSC 75503

Molecular weight: 392.5

CAS: 64048-12-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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