An potent

Torin 2 – 25 mg

Brand:
Cayman
CAS:
1223001-51-1
Storage:
-20
UN-No:
Non-Hazardous - /

Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM).{22455} It shows more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and greater than 100-fold binding selectivity relative to 440 other protein kinases.{22455} Torin 2 has significantly improved bioavailability (54%), metabolic stability, and plasma exposure compared to torin 1 (Item No. 10997).{22455,19694}  

 

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Description

An potent, selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM) with more than 800-fold selectivity for mTOR over PI3K (EC50 = 200 nM) and improved bioavailability compared to Torin 1

Formal name: 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

Synonyms: 

Molecular weight: 432.4

CAS: 1223001-51-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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