A 4-demethoxy analog of daunorubicin which intercalates in DNA and inhibits topoisomerase II

Idarubicin (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
57852-57-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Idarubicin is a 4-demethoxy analog of the leukemia therapeutic daunorubicin (Item No. 14159). Both are anthracycline antibiotics which intercalate in DNA and inhibit topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC50 = 20-120 nM for idarubicin).{22870,22872,22871} Idarubicin is effective in combination therapy for the treatment of different types of leukemia.{22873,22874}  

 

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Description

A 4-demethoxy analog of daunorubicin which intercalates in DNA and inhibits topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC50 = 20-120 nM); effective in combination therapy for the treatment of different types of leukemia

Formal name: (7S,9S)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, monohydrochloride

Synonyms:  4-Demethoxydaunorubicin|4-DMD|NSC 256439

Molecular weight: 534

CAS: 57852-57-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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