An O-methylated isoflavone with weak estrogenic activity (IC50 = 3.94 μM) that has been used in research related phytoestrogen therapeutic activity applied to bone formation

Glycitein – 50 mg

Brand:
Cayman
CAS:
40957-83-3
Storage:
-20
UN-No:
Non-Hazardous - /

Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC50 value of 3.94 μM.{22750} It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor.{22747} It has also been used to attenuate proliferation (10 μM) of aortic smooth muscle cells related to atherosclerotic vascular change in stroke-prone hypertensive rats and to protect against beta amyloid (Aβ)-induced toxicity and oxidative stress (100 μg/ml) in C. elegans expressing human Aβ.{22749,22748}  

 

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Description

An O-methylated isoflavone with weak estrogenic activity (IC50 = 3.94 μM) that has been used in research related phytoestrogen therapeutic activity applied to bone formation, cardiovascular disease, estrogen-dependent cancer, and Alzheimer’s disease

Formal name: 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 284.3

CAS: 40957-83-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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