An antiviral guanosine analog; has antiviral activity in vitro against the herpes simplex viruses

Acyclovir – 500 mg

Brand:
Cayman
CAS:
59277-89-3
Storage:
-20
UN-No:
Non-Hazardous - /

Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}  

 

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Description

An antiviral guanosine analog; has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM); diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase; reduces viral titers in mice infected with the HSV-1 strain SC16

Formal name: 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

Synonyms:  ACV|BW 248U|NSC 645011

Molecular weight: 225.2

CAS: 59277-89-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Chicken Pox & Shingles||Research Area|Infectious Disease|Viral Diseases|Epstein-Barr||Research Area|Infectious Disease|Viral Diseases|HSV

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