A prodrug that is rapidly catabolized in vivo to 5-fluorouracil when administered by rapid injection; inhibits thymidylate synthase (EC50 = 0.6 nM)

Floxuridine – 500 mg

Brand:
Cayman
CAS:
50-91-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Floxuridine is a prodrug that is rapidly catabolized in vivo to 5-fluorouracil when administered by rapid injection.{22465} In addition, floxuridine inhibits thymidylate synthase (EC50 = 0.6 nM), interfering with DNA synthesis.{22463,22473} It has been used to treat various cancers, particularly metastases to the liver.{22466}  

 

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Description

A prodrug that is rapidly catabolized in vivo to 5-fluorouracil when administered by rapid injection; inhibits thymidylate synthase (EC50 = 0.6 nM), interfering with DNA synthesis; used to treat various cancers, particularly metastases to the liver

Formal name: 2′-deoxy-5-fluoro-uridine

Synonyms:  5-FDU|5-Fluorodeoxyuridine|NSC 26740|NSC 27640

Molecular weight: 246.2

CAS: 50-91-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|DNA Damage and Repair

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