An agonist for mCAR (EC50 = 20 nM) that is effective for the mouse receptor but not for human or rat CAR receptors; potently induces cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins

TCPOBOP – 50 mg

Brand:
Cayman
CAS:
76150-91-9
Storage:
-20
UN-No:
Non-Hazardous - /

The mouse constitutive androstane receptor (mCAR), with the retinoid X receptor, binds to the retinoic acid response element to upregulate the expression of proteins that metabolize xenobiotics.{27657} TCPOBOP is an agonist for mCAR (EC50 = 20 nM) that is effective for the mouse receptor but not for human or rat CAR receptors.{27661,27663} Through its effects on mCAR, TCPOBOP potently induces cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins.{27659,27662,27658} The action of TCPOBOP on mCAR-mediated gene expression can be repressed by retinoic acids.{27660}  

 

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Description

An agonist for mCAR (EC50 = 20 nM) that is effective for the mouse receptor but not for human or rat CAR receptors; potently induces cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins

Formal name: 2,2′-[1,4-phenylenebis(oxy)]bis[3,5-dichloro]-pyridine

Synonyms: 

Molecular weight: 402.1

CAS: 76150-91-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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