An inhibitor of DNA topoisomerase I and a derivative of camptothecin; inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells (IC50s = 13 and 2 nM

Topotecan (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
119413-54-6
Storage:
-20
UN-No:
Non-Hazardous - /

Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Item No. 11694).{21114,21115,22689} Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay.{42991} Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells with (IC50s = 33 and 280 nM, respectively.{21114} Formulations containing topotecan have been used in the treatment of small-cell lung cancer.  

 

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Description

An inhibitor of DNA topoisomerase I and a derivative of camptothecin; inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells (IC50s = 13 and 2 nM, respectively); induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively)

Formal name: 10-[(dimethylamino)methyl]-4S-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, monohydrochloride

Synonyms:  NSC 609669|SKF 104864A

Molecular weight: 457.9

CAS: 119413-54-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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