An Oct4-activating compound that activates expression through the Oct4 gene promoter; at 1 μM

OAC1 – 10 mg

Brand:
Cayman
CAS:
300586-90-7
Storage:
-20
UN-No:
Non-Hazardous - /

Octamer-binding transcription factor 4 (Oct4) is a transcription factor that, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC1 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

 

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Description

An Oct4-activating compound that activates expression through the Oct4 gene promoter; at 1 μM, enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts expressing Oct4 with Sox2, Klf4, and c-Myc

Formal name: N-1H-pyrrolo[2,3-c]pyridin-5-yl-benzamide

Synonyms: 

Molecular weight: 237.3

CAS: 300586-90-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Cell Biology|Stem Cell Research|Reprogramming||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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