A sterol-derived hormone that acts as a ligand of DAF-12 (EC50 = 23 nM; 50 nM

(25S)-Δ7-Dafachronic Acid – 1 mg

Brand:
Cayman
CAS:
949004-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM.{22030,22032,22014,22028} At 50 nM, (25S)-Δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults.{22031,22033} Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.{22027}  

 

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Description

A sterol-derived hormone that acts as a ligand of DAF-12 (EC50 = 23 nM; 50 nM, inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults

Formal name: (5α,25S)-3-oxo-cholest-7-en-26-oic acid

Synonyms:  UPF-1404

Molecular weight: 414.6

CAS: 949004-12-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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