A cell-permeable

Dynasore – 25 mg

Brand:
Cayman
CAS:
304448-55-3
Storage:
-20
UN-No:
Non-Hazardous - /

Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM).{22175}{22174} Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands.{22171}{22170}{22172} In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.{22173}{22176}  

 

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Description

A cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM); inhibits clathrin-dependent vesicle formation and endocytosis; can also augment the release of neurotransmitters and secreted cytokines

Formal name: 3-hydroxy-2-[(3,4-dihydroxyphenyl)methylene]hydrazide-2-naphthalenecarboxylic acid

Synonyms: 

Molecular weight: 322.3

CAS: 304448-55-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|GTPases||Research Area|Cell Biology|Cell Signaling|GTPases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases||Research Area|Neuroscience

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