A natural isothiocyanate which induces the expression of phase II detoxification enzymes and activates Nrf2

Iberin – 1 mg

Brand:
Cayman
CAS:
505-44-2
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Iberin is a natural isothiocyanate found in cruciferous plants.{21884} When introduced into the daily diet of rats or added to rat hepatocytes (40 μM), it induces the expression of phase II detoxification enzymes, including quinone reductase and glutathione S-transferase.{21884,21883} In addition, iberin activates the nuclear factor E2-related protein Nrf2, which promotes the expression of antioxidant and phase II genes.{21883,21880} Iberin also induces the apoptosis of some cancer cell lines.{21880,21881} Interestingly, iberin also acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth (IC50 = 31-62 μM).{21882}  

 

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Description

A natural isothiocyanate which induces the expression of phase II detoxification enzymes and activates Nrf2, promoting the expression of antioxidant and phase II genes; acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth (IC50 = 31-62 μM)

Formal name: 1-isothiocyanato-3-(methylsulfinyl)-propane

Synonyms:  NSC 321801

Molecular weight: 163.3

CAS: 505-44-2

Purity: ≥95% (NMR)

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products|Isothiocyanates||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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