A cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM); dimishes neuronal cell death induced by mutant huntingtin fragment in culture; down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo

AK-7 – 50 mg

Brand:
Cayman
CAS:
420831-40-9
Storage:
-20
UN-No:
Non-Hazardous - /

The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates.{21799} It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases.{21799,21800,21803} AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).{21802} In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment.{21802} In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.{21802}  

 

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Description

A cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM); dimishes neuronal cell death induced by mutant huntingtin fragment in culture; down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo

Formal name: N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide

Synonyms: 

Molecular weight: 437.4

CAS: 420831-40-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease

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