A natural diterpene which elevates serum cholesterol and triglycerides in humans

Cafestol – 50 mg

Brand:
Cayman
CAS:
469-83-0
Storage:
-20
UN-No:
Non-Hazardous - /

Cafestol is a natural diterpene which is abundant in unfiltered coffee.{21876,21885} It elevates serum cholesterol and triglycerides in humans, an effect which does not seem to occur in monkeys, hamsters, rats, or gerbils.{21889,21887} Dietary cafestol does increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is associated with selective activation of farnesoid X receptors and pregnane X receptors.{21886} Cafestol (20 μM) also inhibits the proliferation of human umbilical vein endothelial cells and prevents their migration and tube formation on Matrigel™.{21890}  

 

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Description

A natural diterpene which elevates serum cholesterol and triglycerides in humans, an effect which does not seem to occur in monkeys, hamsters, rats or gerbils; increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is associated with selective activation of FXR and PXR

Formal name: 3bS,4,5,6,7R,8R,9,10,10aR,10bS,11,12-dodecahydro-7-hydroxy-10b-methyl-5aS,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol

Synonyms: 

Molecular weight: 316.4

CAS: 469-83-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Vasculature|Angiogenesis

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