A PAO inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM

MDL 72527 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
93565-01-6
Storage:
-20
UN-No:
Non-Hazardous - /

MDL 72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively).{33211} It does not inhibit monoamine oxidase or D-amino acid oxidase. MDL 72527 inhibits PAO-dependent H2O2 production in vitro and in vivo and is used to study the role of PAO activity in diverse models, including infection, cancer, and hyperoxia.{33209,33210,33212}  

 

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Description

A PAO inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively); inhibits PAO-dependent H2O2 production in vitro and in vivo

Formal name: N1,N4-di-2,3-butadien-1-yl-1,4-butanediamine, dihydrochloride

Synonyms: 

Molecular weight: 265.2

CAS: 93565-01-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease

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