An inhibitor of mitochondrial complex I; inhibits NADH/DB oxidoreductase and NADH oxidase (IC50s = 28.8 and 5.1 nM

Rotenone – 25 mg

Brand:
Cayman
CAS:
83-79-4
Storage:
-20
UN-No:
- 2811 / 6.1

Rotenone is a classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC50 values of 28.8 and 5.1 nM, respectively.{25505} In substantia nigra pars compacta neurons, it activates ATP-sensitive potassium channels and increases the production of reactive oxygen species (ROS) in the mitochondria, effects that are decreased by the antioxidant trolox (Item No. 10011659).{25508} In rodents, rotenone induces dopaminergic cell death in the substantia nigra, formation of cytoplasmic inclusions similar to Lewy bodies, oxidative damage to proteins, and parkinsonian symptoms of bradykinesia and rigidity.{25506} In a rat model of Parkinson’s disease, chronic rotenone administration of 1.5 and 2.5 mg/kg per day for two months reduces tyrosine hydroxylase levels in the posterior striatum and prefrontal cortex, induces catalepsy, and decreases spontaneous locomotion and exploration in the open field test.{41910} Formulations containing rotenone have been used as insecticides and piscicides.{25504}  

 

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Description

An inhibitor of mitochondrial complex I; inhibits NADH/DB oxidoreductase and NADH oxidase (IC50s = 28.8 and 5.1 nM, respectively); increases ROS production in the mitochondria of substantia nigra pars compacta neurons; induces Parkinson-like neuropathology and behavior in rodents; reduces tyrosine hydroxylase levels in the posterior striatum and prefrontal cortex, induces catalepsy, and decreases spontaneous locomotion and exploration in the open field test in rats at 1.5 and 2.5 mg/kg per day for two months; commonly used as a model of Parkinson’s in rodents

Formal name: (2R,6aS,12aS)-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

Synonyms:  Nicouline|NSC 26258|NSC 8505|Tubatoxin

Molecular weight: 394.4

CAS: 83-79-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function||Research Area|Toxicology|Environmental

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