An antagonist of MCH1 (IC50 = 0.5 nM); reduces cumulative body weight and food intake in diet-induced obese rats at 1 and 3 mg/kg; decreases marble-burying behavior in mice without affecting performance in the rotorod test at 10 and 30 mg/kg; reduces immobility time in the forced swim and tail suspension tests in mice at 3 and 10 mg/kg

GW 803430 – 10 mg

Brand:
Cayman
CAS:
515141-51-2
Storage:
-20
UN-No:
Non-Hazardous - /

GW 803430 is an antagonist of melanin-concentrating hormone receptor 1 (MCH1; IC50 = 0.5 nM).{45224} It reduces cumulative body weight and food intake in diet-induced obese rats when administered at doses of 1 and 3 mg/kg.{45225} GW 803430 (10 and 30 mg/kg) decreases marble-burying behavior in mice, indicating anxiolytic activity, but does not affect performance in the rotorod test. It also reduces immobility time in the forced swim and tail suspension tests in mice at doses of 3 and 10 mg/kg, respectively, indicating antidepressant-like activity.  

 

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Description

An antagonist of MCH1 (IC50 = 0.5 nM); reduces cumulative body weight and food intake in diet-induced obese rats at 1 and 3 mg/kg; decreases marble-burying behavior in mice without affecting performance in the rotorod test at 10 and 30 mg/kg; reduces immobility time in the forced swim and tail suspension tests in mice at 3 and 10 mg/kg, respectively,

Formal name: 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one

Synonyms:  GW 3430

Molecular weight: 482

CAS: 515141-51-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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