An analog of adenosine monophosphate that has antiviral activity; converted by cellular enzymes to tenofovir diphosphate

Tenofovir – 5 mg

Brand:
Cayman
CAS:
147127-20-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tenofovir is an analog of adenosine monophosphate that has antiviral activity.{24520,24521} It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.{24519,24528} Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.{24528} For in vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) (Item No. 16922), which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.{24528}  

 

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Description

An analog of adenosine monophosphate that has antiviral activity; converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and HBV polymerase

Formal name: P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-phosphonic acid

Synonyms:  (R)-PMPA|GS-1275|GS-1278|TDF

Molecular weight: 287.2

CAS: 147127-20-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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