A potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM); selective for ceramide kinase over SPHK1

NVP-231 – 5 mg

Brand:
Cayman
CAS:
362003-83-6
Storage:
-20
UN-No:
Non-Hazardous - /

NVP-231 is a potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM).{22065} It is selective for ceramide kinase over SPHK1, SPHK2, DAGKa, PI3Ka, PI4Kb, VPS34, GCS, SMS-1, and CERT (IC50s = >5 mM). NVP-231 inhibits formation of ceramide-1-phosphate (C1P; IC50 = 10 nM) and cell death in ceramide kinase overexpressing COS cells (COS-CerK). It also inhibits C1P formation and tube formation in murine dermal microvascular endothelial cells when used at a concentration of 100 nM.{22067}  

 

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Description

A potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM); selective for ceramide kinase over SPHK1, SPHK2, DAGKa, PI3Ka, PI4Kb, VPS34, GCS, SMS-1, and CERT (IC50s = >5 mM); inhibits C1P formation and cell death in COS-CerK cells; inhibits C1P formation and tube formation in murine dermal microvascular endothelial cells at 100 nM,

Formal name: N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide

Synonyms: 

Molecular weight: 431.6

CAS: 362003-83-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Lipid Biochemistry|Sphingolipids

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