Reversibly binds tubulin and alters GTP hydrolysis as well as microtubule dynamics; nanomolar concentrations reduce both microtubule elongation and shortening velocities

Nocodazole – 5 mg

Brand:
Cayman
CAS:
31430-18-9
Storage:
-20
UN-No:
Non-Hazardous - /

Nocodazole reversibly binds tubulin and alters tubulin-associated GTP hydrolysis as well as microtubule dynamics.{22044,21248} While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture.{22043,22042} Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase.{22045,22043} Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.{21248}  

 

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Description

Reversibly binds tubulin and alters GTP hydrolysis as well as microtubule dynamics; nanomolar concentrations reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase; also used to induce the formation of Golgi ministacks in eukaryotic cells

Formal name: N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester

Synonyms:  NSC 238159|Oncodazole|R 17934

Molecular weight: 301.3

CAS: 31430-18-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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