An HDAC inhibitor

5-Nitroso-8-quinolinol – 10 mg

Brand:
Cayman
CAS:
3565-26-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

5-Nitroso-8-quinolinol is a chemically unique HDAC inhibitor that harbors a different Zn2+ chelation motif compared to SAHA.{21741,21740} As an antitumor agent, 10 μM 5-nitroso-8-quinolinol can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells.{21741,21740} Additionally, 5-nitroso-8-quinolinol inhibits T. gondii tachyzoite propagation in human fibroblasts with an EC50 value of 80 nM and inhibits P. falciparum growth in human red blood cells with an EC50 value of 1.3 μM.{21739}  

 

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Description

An HDAC inhibitor, antitumor agent that at 10 μM can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells; inhibits T. gondii tachyzoite propagation in human fibroblasts (EC50 = 80 nM) and inhibits P. falciparum growth in human red blood cells (EC50 = 1.3 μM)

Formal name: 5-nitroso-8-quinolinol

Synonyms:  Hydron III|NSC 3852

Molecular weight: 174.2

CAS: 3565-26-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Parasitic Diseases|Toxoplasmosis

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