An antiviral nucleoside analog and inhibitor of HBV reverse transcriptase (IC50 = 0.5 nM); reduces virion DNA in the culture supernatant of HepG2/2.15 cells infected with HBV (EC50 = 3.75 nM); reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection at 1 mg/kg

Entecavir (hydrate) – 100 mg

Brand:
Cayman
CAS:
209216-23-9
Storage:
-20
UN-No:
Non-Hazardous - /

Entecavir is an antiviral nucleoside analog of 2′-deoxyguanosine (Item No. 9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM).{22164,59703} It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate.{53861,59703} Entecavir reduces virion DNA in the culture supernatant of HepG2/2.15 cells infected with hepatitis B virus (HBV; EC50 = 3.75 nM).{22164} It reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection when administered at a dose of 1 mg/kg.{22166} Formulations containing entecavir have been used in the treatment of chronic HBV infection.  

 

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Description

An antiviral nucleoside analog and inhibitor of HBV reverse transcriptase (IC50 = 0.5 nM); reduces virion DNA in the culture supernatant of HepG2/2.15 cells infected with HBV (EC50 = 3.75 nM); reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection at 1 mg/kg

Formal name: 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, monohydrate

Synonyms:  BMS 200475|SQ 34,676

Molecular weight: 295.3

CAS: 209216-23-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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