A potent group IVA cPLA2 inhibitor (XI(50) = 0.022); reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw (ED50 = 1.2 mg/kg); does not inhibit COX activity or interfere with CB1 receptor signaling

AX 048 – 500 µg

Brand:
Cayman
CAS:
873079-69-7
Storage:
-20
UN-No:
Non-Hazardous - /

The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes.{1474} AX 048 is a potent group IVA cPLA2 inhibitor that demonstrates 50% inhibition of the enzyme at a mole fraction (XI(50)) of 0.022. Pretreatment with AX 048 (ED50 = 1.2 mg/kg) dose-dependently reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw.{18000} At concentrations as high as 30 µM, AX 048 does not inhibit COX activity or interfere with central cannabinoid receptor signaling.{18000}  

 

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Description

A potent group IVA cPLA2 inhibitor (XI(50) = 0.022); reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw (ED50 = 1.2 mg/kg); does not inhibit COX activity or interfere with CB1 receptor signaling

Formal name: 4-[(1,2-dioxohexadecyl)amino]-butanoic acid, ethyl ester

Synonyms: 

Molecular weight: 383.6

CAS: 873079-69-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases||Research Area|Neuroscience|Pain Research

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