Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2

Misoprostol (free acid) – 10 mg

Brand:
Cayman
CAS:
112137-89-0
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4 receptors.{2313,1754,1752,1611} It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),{1752} and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM){1611} in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; Item No. 10006317) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}  

 

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Description

Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4 receptors.{2313,1754,1752,1611} It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),{1752} and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM){1611} in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; Item No. 10006317) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}

Formal name: 9-oxo-11α,16-dihydroxy-16-methyl-prost-13E-en-1-oic acid

Synonyms: 

Molecular weight: 368.5

CAS: 112137-89-0

Purity: ≥97%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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