A PGE1 analog and agonist of EP2 and EP3 receptors; binds to EP1

Misoprostol – 10 mg

Brand:
Cayman
CAS:
59122-46-2
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Misoprostol is an analog of prostaglandin E1 (PGE1; Item No. 13010) and an agonist of the PGE2 receptor subtypes EP2 and EP3.{8322,1752,59038} It binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 μM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 μM for all).{8322} Misoprostol inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC50s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP2 and EP3 receptors, respectively.{59038,3411} It inhibits FMLP-induced superoxide anion generation in human neutrophils (EC50 = 0.35 μM).{1752} Misoprostol inhibits ethanol-induced gastric lesion formation in rats (ED50 = 0.31 μg/kg).{1754} Formulations containing misoprostol have been used in the prevention of NSAID-induced gastric ulcers.  

 

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Description

A PGE1 analog and agonist of EP2 and EP3 receptors; binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 μM, respectively), and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 μM for all); inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC50s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP2 and EP3 receptors, respectively; inhibits FMLP-induced superoxide anion generation in human neutrophils (EC50 = 0.35 μM); inhibits ethanol-induced gastric lesion formation in rats (ED50 = 0.31 μg/kg)

Formal name: 9-oxo-11α,16-dihydroxy-16-methyl-prost-13E-en-1-oic acid, methyl ester

Synonyms:  SC 29333

Molecular weight: 382.5

CAS: 59122-46-2

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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