An inhibitor of hog liver esterase and hog pancreas lipase (IC50s = 29 and 0.14 ng/ml

Valilactone – 1 mg

Brand:
Cayman
CAS:
113276-96-3
Storage:
-20
UN-No:
Non-Hazardous - /

Valilactone is an esterase inhibitor produced by a cultured strain of soil actinomycetes.{32633} It is reported to inhibit hog liver esterase and hog pancreas lipase with IC50 values of 29 and 0.14 ng/ml, respectively.{32633} Valilactone can also inhibit fatty acid synthase with an IC50 value of 0.30 µM and demonstrates selective toxicity towards MDA-MB-231 breast cancer cells with an IC50 value of 10.5 µM.{17922}  

 

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Description

An inhibitor of hog liver esterase and hog pancreas lipase (IC50s = 29 and 0.14 ng/ml, respectively); also inhibits fatty acid synthase (IC50 = 0.30 µM) and demonstrates selective toxicity towards MDA-MB-231 breast cancer cells (IC50 = 10.5 µM)

Formal name: N-formyl-L-valine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]hexyl ester

Synonyms:  (-)-Valilactone

Molecular weight: 397.6

CAS: 113276-96-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Death

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