A potent inhibitor of Nampt (IC50 = 3 nM); induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy

GPP 78 – 1 mg

Brand:
Cayman
CAS:
1202580-59-3
Storage:
-20
UN-No:
De Minimis - 1230 / 3|6.1

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM).{17893} It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.{13670}  

 

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Description

A potent inhibitor of Nampt (IC50 = 3 nM); induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy

Formal name: N-[1,1′-biphenyl]-2-yl-4-(3-pyridinyl)-1H-1,2,3-triazole-1-octanamide

Synonyms:  CAY10618|NMPRTase Inhibitor

Molecular weight: 439.6

CAS: 1202580-59-3

Purity: ≥95%

Formulation: A solution in methanol

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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