A nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases; inhibits bone resorption in vitro with an IC50 value of 2 nM

Alendronate (sodium hydrate) – 1 g

Brand:
Cayman
CAS:
121268-17-5
Storage:
-20
UN-No:
Non-Hazardous - /

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18286} Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.{18287,18285,18282} It inhibits bone resorption in vitro with an IC50 value of 2 nM.{18288} In vivo, alendronate significantly increases (or prevents a decrease in) bone mineral density and reduces vertebral fractures.{18285,18282,17616}  

 

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Description

A nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases; inhibits bone resorption in vitro with an IC50 value of 2 nM

Formal name: P,P’-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, monosodium salt trihydrate (1:1:3)

Synonyms:  Adronat|Fosamax|G-704650|MK-217

Molecular weight: 325.1

CAS: 121268-17-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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