A potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM); prevents CXCR4/SDF-1-mediated modulation of cAMP (EC50 = 1.2 nM) in cells; blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM)

WZ811 – 10 mg

Brand:
Cayman
CAS:
55778-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM).{17800} It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM).{17800} The effectiveness of WZ811 in animals remains to be elucidated.  

 

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Description

A potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM); prevents CXCR4/SDF-1-mediated modulation of cAMP (EC50 = 1.2 nM) in cells; blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM)

Formal name: N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine

Synonyms: 

Molecular weight: 290.4

CAS: 55778-02-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Migration & Metastasis

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