An analog of ceramide and a GPR119 agonist (EC50 = 12 µM); induces cell death in F-11 murine neuroblastoma and U-87 human astrocytoma cells at 100 µM; induces apoptosis in rapidly dividing cells and prevents teratoma formation in a neonatal mouse engraftment model of teratoma formation

Oleoyl Serinol – 50 mg

Brand:
Cayman
CAS:
72809-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells.{39726} It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine neuroblastoma and apoptosis in U-87 human astrocytoma cells when used at a concentration of 100 µM.{10417} Oleoyl serinol (80 µM) induces formation of a complex including PAR-4 and PKCζ in embryoid body-derived cells, decreases the levels of the pluripotency marker Oct-4 and prostate apoptosis response-4 (PAR-4), which mediates ceramide-induced apoptosis in embryonic stem cells.{39727} It induces apoptosis selectively in rapidly dividing cells over differentiated cells as well as prevents teratoma formation and promotes neural differentiation in a neonatal mouse engraftment model of teratoma formation.  

 

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Description

An analog of ceramide and a GPR119 agonist (EC50 = 12 µM); induces cell death in F-11 murine neuroblastoma and U-87 human astrocytoma cells at 100 µM; induces apoptosis in rapidly dividing cells and prevents teratoma formation in a neonatal mouse engraftment model of teratoma formation

Formal name: N-[2-hydroxy-1-(hydroxymethyl)ethyl]-9Z-octadecenamide

Synonyms:  N-Oleoyl Serinol|S-18

Molecular weight: 355.6

CAS: 72809-08-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research

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