A proton pump inhibitor; inhibits K+ and H+ accumulation in gastric microsomes (IC50s = 6.3 and 7 µM

Lansoprazole – 500 mg

Brand:
Cayman
CAS:
103577-45-3
Storage:
-20
UN-No:
Non-Hazardous - /

Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.  

 

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Description

A proton pump inhibitor; inhibits K+ and H+ accumulation in gastric microsomes (IC50s = 6.3 and 7 µM, respectively); inhibits H+/K+-ATPase activity by approximately 60% at 10 µM

Formal name: 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole

Synonyms:  AG-1749

Molecular weight: 369.4

CAS: 103577-45-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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