A sugar sulfamate with anticonvulsant activity; inhibits carbonic anhydrase from intact human erythrocytes (Ki = ~200 μM)

Topiramate – 500 mg

Brand:
Cayman
CAS:
97240-79-4
Storage:
-20
UN-No:
Non-Hazardous - /

Topiramate is a sugar sulfamate with anticonvulsant activity.{18290} It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro.{18290,32575,48075} It also increases GABAA receptor-mediated chloride ion flux.{48075} Topiramate inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.).{18290} Formulations containing topiramate have been used in the treatment of epilepsy and prophylaxis of migraine headaches.  

 

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Description

A sugar sulfamate with anticonvulsant activity; inhibits carbonic anhydrase from intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels, and kainite-induced currents in vitro; increases GABAA receptor-mediated chloride ion flux; inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.)

Formal name: 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose, 1-sulfamate

Synonyms:  McN 4853|RWJ 17021|TPM

Molecular weight: 339.4

CAS: 97240-79-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders

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