An antagonist of lipid A activation of TLR4 (IC50 =1.68 μM)

CAY10614 – 10 mg

Brand:
Cayman
CAS:
1202208-36-3
Storage:
-20
UN-No:
Non-Hazardous - /

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.{17575} It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.{17575}  

 

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Description

An antagonist of lipid A activation of TLR4 (IC50 =1.68 μM), in a cell-based assay; significantly improves survival of mice given intraperitoneal LPS

Formal name: N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide

Synonyms: 

Molecular weight: 756

CAS: 1202208-36-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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