A selective inhibitor of Aurora A kinase (IC50s = 1 and 1

MLN8237 – 1 mg

Brand:
Cayman
CAS:
1028486-01-2
Storage:
-20
UN-No:
Non-Hazardous - /

MLN8237 is a selective inhibitor of Aurora A kinase (IC50s = 1 and 1,100 nM for Aurora A and B, respectively).{28846,17545,27645} At 20 mg/kg it inhibits tumor growth in nude mice bearing Calu-6 human lung tumor xenografts.{28846} MLN8237 has been evaluated for treatment of hematological malignancies or solid tumors in multiple phase II and III clinical trials.{28846}  

 

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Description

A selective inhibitor of Aurora A kinase (IC50s = 1 and 1,100 nM for Aurora A and B, respectively); inhibits tumor growth in nude mice bearing Calu-6 human lung tumor xenografts at 20 mg/kg

Formal name: 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy benzoic acid

Synonyms:  Alisertib

Molecular weight: 518.9

CAS: 1028486-01-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Aurora Signaling

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